RASEF

Across TCGA patient cohorts, RASEF mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASEF-associated genes across cancer lineages are FoxM1, INPP4B, and JNK_pT183_Y185. Each is linked with RASEF in more than 2 cancer types. Because this analysis shows association rather than direction, both RASEF-to-partner and partner-to-RASEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RASEF-low versus RASEF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASEF→partner) and Y-score (partner→RASEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.216	+1.502	.023	.030	3	3
UCEC	INPP4B →	-0.295	-2.459	.012	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.153	-1.700	.013	.042	3	2
UCEC	Ku80 →	+0.213	+2.261	.014	.001	3	2
UCEC	Annexin-1 →	+0.599	+3.720	.001	<.001	3	2
UCEC	STAT5a →	+0.407	+1.502	.005	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FoxM1 by RASEF expression — UCEC

Explore this box plot interactively →