RASD2

Across TCGA patient cohorts, RASD2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASD2-associated genes across cancer lineages are Chk2, eIF4E, and A-Raf_pS299. Each is linked with RASD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASD2-to-partner and partner-to-RASD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2 grouped by RASD2-low versus RASD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASD2→partner) and Y-score (partner→RASD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk2 →	+0.295	+3.000	.021	.036	3	2
UCEC	eIF4E →	+0.168	+3.335	.030	.005	3	1
UCEC	A-Raf_pS299 →	-0.166	-2.459	<.001	.018	3	1
UCEC	ERK2 →	+0.221	+2.700	.001	.005	3	1
UCEC	IGFBP2 →	-0.677	-2.247	.004	.001	3	1
UCEC	INPP4B →	-0.300	-2.459	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Chk2 by RASD2 expression — SKCM

Explore this box plot interactively →