RASAL3

Across TCGA patient cohorts, RASAL3 mutation is significantly associated with the RNA expression of many other genes, with 2,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASAL3-associated genes across cancer lineages are FAXDC2, MBD2, and TAAR8. Each is linked with RASAL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASAL3-to-partner and partner-to-RASAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAXDC2 grouped by RASAL3-low versus RASAL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASAL3→partner) and Y-score (partner→RASAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAXDC2 →	-0.534	-2.989	<.001	<.001	3	3
SKCM	MBD2 →	+0.471	+3.359	.002	.004	3	3
SKCM	TAAR8 →	+0.185	+2.117	<.001	.005	3	2
LUSC	SPANXA1 →	+0.187	+3.380	<.001	<.001	3	2
UCEC	LIN7C →	+0.360	+1.522	.008	.009	3	2
UCEC	DRD2 →	-0.368	-2.360	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,220 associations by consensus.

FAXDC2 by RASAL3 expression — UCEC

Explore this box plot interactively →