RASAL3

Across TCGA patient cohorts, RASAL3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASAL3-associated genes across cancer lineages are PDCD4, C-Raf, and Chk2_pT68. Each is linked with RASAL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASAL3-to-partner and partner-to-RASAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by RASAL3-low versus RASAL3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASAL3→partner) and Y-score (partner→RASAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.588	-3.169	.007	.019	3	3
COAD	C-Raf →	+0.165	+2.815	.039	.036	3	3
UCEC	Chk2_pT68 →	-0.134	-2.433	.022	.018	3	3
LUSC	MIG-6 →	+0.131	+3.013	.014	.018	2	3
COAD	ASNS →	+0.755	+2.815	<.001	.036	2	3
COAD	Caspase-7-cleavedD198 →	+1.720	+2.815	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PDCD4 by RASAL3 expression — SKCM

Explore this box plot interactively →