RASAL2

Across TCGA pan-cancer cohorts, RASAL2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RASAL2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RASAL2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RASAL2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where RASAL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.983	0.852	.011	22	view →
LUAD	OS	Quartile	All	0.725	1.000	.026	10	view →
CCRCC	OS	Median	III,IV	0.818	0.582	.022	9	view →
LSCC	DFS	Median	II,III,IV	0.554	0.799	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RASAL2–UCEC (OS)

Open the UCEC breakdown →