RASAL2

Across TCGA patient cohorts, RASAL2 mutation is significantly associated with the RNA expression of many other genes, with 5,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASAL2-associated genes across cancer lineages are SNRPGP2, E2F1, and SUPV3L1. Each is linked with RASAL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RASAL2-to-partner and partner-to-RASAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP2 grouped by RASAL2-low versus RASAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASAL2→partner) and Y-score (partner→RASAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP2 →	+0.376	+2.190	<.001	<.001	3	4
UCEC	E2F1 →	+0.638	+2.369	<.001	<.001	3	4
UCEC	SUPV3L1 →	+0.250	+1.412	.004	<.001	3	3
UCEC	TEDC2 →	+0.507	+1.568	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.632	+1.894	<.001	<.001	3	3
UCEC	CDC25A →	+0.566	+1.860	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,830 associations by consensus.

SNRPGP2 by RASAL2 expression — UCEC

Explore this box plot interactively →