RASAL2

Across TCGA cell cohorts, RASAL2 mutation is significantly associated with the RNA expression of many other genes, with 403 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASAL2-associated genes across cancer lineages are TAS2R38, SPATA48, and DEFB108B. Each is linked with RASAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASAL2-to-partner and partner-to-RASAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R38 grouped by RASAL2-low versus RASAL2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASAL2→partner) and Y-score (partner→RASAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAS2R38 →	+0.169	+4.350	<.001	.005	3	2
CNS	SPATA48 →	+0.027	+5.357	<.001	.001	3	2
BLOOD_Leukemia	DEFB108B →	+0.127	+4.269	<.001	.002	3	2
PANCREAS	SERPINA11 →	+0.018	+4.491	<.001	.003	3	1
PANCREAS	OR5G3 →	+0.032	+4.614	<.001	.004	3	1
BLOOD_Lymphoma	DPPA2 →	+0.237	+4.523	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 403 associations by consensus.

TAS2R38 by RASAL2 expression — BLOOD_Lymphoma

Explore this box plot interactively →