RASAL1

Across TCGA pan-cancer cohorts, RASAL1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RASAL1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RASAL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RASAL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where RASAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.996	0.733	.003	32	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.010	14	view →
LSCC	DFS	Median	All	0.382	1.000	<.001	11	view →
HNSC	OS	Median	All	1.000	0.484	.038	10	view →
PDAC	OS	Median	IV	0.381	0.951	.006	9	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	DFS	Quartile	All	0.871	0.674	.024	4	view →
UCEC	DFS	Quartile	All	1.000	0.911	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RASAL1–CCRCC (OS)

Open the CCRCC breakdown →