RASAL1

Across TCGA pan-cancer cohorts, RASAL1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RASAL1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where RASAL1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RASAL1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

PDAC, LUAD, and HNSC are the cancer types where RASAL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASAL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.524	<.001	10	view →
LUAD	Male	II,III,IV	+0.785	<.001	9	view →
HNSC	Male	All	−0.906	<.001	8	view →
LSCC	Male	III,IV	+0.823	<.001	8	view →
COAD	Female	IV	−1.020	.004	5	view →
CCRCC	All	All	+0.264	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RASAL1–PDAC

Open the PDAC breakdown →