RASAL1

Across TCGA patient cohorts, RASAL1 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RASAL1-associated genes across cancer lineages are LKB1, Akt, and ATM. Each is linked with RASAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASAL1-to-partner and partner-to-RASAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by RASAL1-low versus RASAL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASAL1→partner) and Y-score (partner→RASAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LKB1 →	+0.135	+2.708	<.001	.003	3	3
COAD	Akt →	-0.533	-2.321	.004	.033	3	3
COAD	ATM →	-0.590	-1.991	<.001	.031	3	3
COAD	Cyclin-E2 →	+0.226	+1.762	.016	.049	3	3
SKCM	STAT3_pY705 →	-0.394	-3.700	<.001	.001	3	3
COAD	eIF4G →	-0.605	-3.000	.010	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

LKB1 by RASAL1 expression — COAD

Explore this box plot interactively →