RASA4B

Across TCGA pan-cancer cohorts, RASA4B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RASA4B data layer compared with 4 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher RASA4B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RASA4B expression acts as an unfavorable survival marker, although some lineages such as DLBC and PAAD show a favorable association.

DLBC, ACC, and STAD are the cancer types where RASA4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.971	0.451	<.001	62	view →
ACC	DFS	Quartile	II,III,IV	0.111	0.803	.001	48	view →
STAD	DFS	Median	All	0.450	0.629	.002	32	view →
PAAD	OS	Tertile	All	0.548	0.272	.002	31	view →
KIRP	DFS	Quartile	All	0.419	0.833	.002	30	view →
THCA	DFS	Quartile	III,IV	0.481	0.863	.002	26	view →
COAD	DFS	Median	II,III,IV	0.275	0.561	.016	23	view →
LGG	OS	Median	All	0.864	0.753	<.001	14	view →
LUSC	OS	Tertile	III,IV	0.456	0.819	<.001	12	view →
GBM	OS	Median	All	0.488	0.346	.020	9	view →
UCEC	DFS	Tertile	All	0.858	0.918	.022	8	view →
OV	DFS	Median	IV	0.344	0.550	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RASA4B–DLBC (DFS)

Open the DLBC breakdown →