RASA4

Across TCGA pan-cancer cohorts, RASA4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RASA4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RASA4 RNA is repressed in tumor relative to normal tissue. In most cancer types RASA4 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

BLCA, LIHC, and UCEC are the cancer types where RASA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.263	.007	7	view →
LIHC	Female	All	+0.079	<.001	7	view →
UCEC	All	All	−0.683	<.001	6	view →
BRCA	All	All	−0.422	<.001	6	view →
LUSC	Male	All	−0.270	<.001	6	view →
KIRP	All	III,IV	−0.230	.002	6	view →
CHOL	All	All	+0.178	.001	3	view →
THCA	All	All	+0.114	.006	3	view →
PRAD	All	All	−0.163	<.001	2	view →
LUAD	All	All	−0.105	.042	1	view →
HNSC	Male	IV	−0.101	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RASA4–BLCA

Open the BLCA breakdown →