RASA4

Across TCGA pan-cancer cohorts, RASA4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RASA4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RASA4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RASA4 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where RASA4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASA4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−0.954	<.001	8	view →
LSCC	All	All	−0.815	<.001	5	view →
HNSC	All	All	−0.317	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

RASA4–LUAD

Open the LUAD breakdown →