RASA2

Across TCGA patient cohorts, RASA2 mutation is significantly associated with the RNA expression of many other genes, with 2,745 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASA2-associated genes across cancer lineages are SNRPD3, VARS2, and RNU1-17P. Each is linked with RASA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASA2-to-partner and partner-to-RASA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD3 grouped by RASA2-low versus RASA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASA2→partner) and Y-score (partner→RASA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNRPD3 →	+0.339	+2.341	.008	.003	3	3
SKCM	VARS2 →	+0.418	+2.366	.005	.003	3	3
UCEC	RNU1-17P →	+0.154	+1.935	<.001	.006	3	3
SKCM	RPSAP38 →	+0.024	+2.144	.004	.003	3	3
SKCM	DXO →	+0.434	+3.488	.003	.002	3	3
BRCA	MIR6766 →	+0.507	+5.575	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,745 associations by consensus.

SNRPD3 by RASA2 expression — SKCM

Explore this box plot interactively →