RASA2

Across TCGA patient cohorts, RASA2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASA2-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and MEK1. Each is linked with RASA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASA2-to-partner and partner-to-RASA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RASA2-low versus RASA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASA2→partner) and Y-score (partner→RASA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.675	+2.242	.001	.005	3	3
UCEC	ERK2 →	+0.168	+1.415	.013	.043	3	2
UCEC	MEK1 →	+0.287	+2.000	.026	.003	3	2
UCEC	mTOR_pS2448 →	-0.119	-2.687	.024	.005	3	2
UCEC	Notch1 →	+0.157	+2.235	.001	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.463	-2.379	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by RASA2 expression — UCEC

Explore this box plot interactively →