RASA1

Across TCGA pan-cancer cohorts, RASA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RASA1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RASA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RASA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where RASA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.755	0.934	<.001	49	view →
LSCC	OS	Median	All	0.721	0.889	.010	8	view →
CCRCC	OS	Median	III,IV	0.485	1.000	.036	4	view →
UCEC	DFS	Tertile	All	0.966	0.821	.034	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
HNSC	OS	Quartile	III,IV	0.812	0.564	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RASA1–PDAC (OS)

Open the PDAC breakdown →