RASA1

Across TCGA patient cohorts, RASA1 mutation is significantly associated with the RNA expression of many other genes, with 3,748 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASA1-associated genes across cancer lineages are EIF5A, TXNDC17, and MPDU1. Each is linked with RASA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RASA1-to-partner and partner-to-RASA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF5A grouped by RASA1-low versus RASA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASA1→partner) and Y-score (partner→RASA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF5A →	+0.581	+3.834	<.001	<.001	3	4
STAD	TXNDC17 →	+0.508	+3.459	.005	.005	3	3
STAD	MPDU1 →	+0.561	+3.208	.002	.009	3	3
STAD	LRMDA →	-0.561	-3.321	.009	.009	3	3
STAD	GEMIN4 →	+0.586	+3.459	.005	.005	3	3
STAD	RNU2-27P →	+0.828	+3.182	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,748 associations by consensus.

EIF5A by RASA1 expression — COAD

Explore this box plot interactively →