RASA1

Across TCGA patient cohorts, RASA1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASA1-associated genes across cancer lineages are ATM, PCNA, and c-Kit. Each is linked with RASA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RASA1-to-partner and partner-to-RASA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RASA1-low versus RASA1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASA1→partner) and Y-score (partner→RASA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ATM →	-0.652	-3.169	.002	.018	3	4
UCEC	PCNA →	+0.188	+1.502	.001	<.001	3	4
LUSC	c-Kit →	-0.372	-2.321	.049	.033	3	2
COAD	NF-kB-p65_pS536 →	-0.652	-3.157	.004	.018	3	2
COAD	PDCD4 →	-0.414	-2.450	.023	.020	3	2
COAD	Smad4 →	+0.133	+3.169	.020	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ATM by RASA1 expression — LUSC

Explore this box plot interactively →