RASA1

Across TCGA cell cohorts, RASA1 mutation is significantly associated with the RNA expression of many other genes, with 471 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASA1-associated genes across cancer lineages are REG3A, WFDC13, and WFDC10B. Each is linked with RASA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASA1-to-partner and partner-to-RASA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3A grouped by RASA1-low versus RASA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASA1→partner) and Y-score (partner→RASA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	REG3A →	+0.073	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	WFDC13 →	+0.163	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	WFDC10B →	+0.493	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	FAM24A →	+0.055	+5.247	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	PDE6H →	+0.049	+4.362	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	SCRT2 →	+0.010	+4.362	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 471 associations by consensus.

REG3A by RASA1 expression — LUNG_SCLC

Explore this box plot interactively →