RARS2

Across TCGA patient cohorts, RARS2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARS2-associated genes across cancer lineages are GSK3-a-b, ERK2, and MEK1. Each is linked with RARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RARS2-to-partner and partner-to-RARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3-a-b grouped by RARS2-low versus RARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARS2→partner) and Y-score (partner→RARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK3-a-b →	+0.155	+2.321	.005	.034	3	2
UCEC	ERK2 →	+0.204	+2.584	.010	.010	3	1
UCEC	MEK1 →	+0.371	+2.584	.014	.010	3	1
UCEC	mTOR_pS2448 →	-0.166	-1.980	.007	.030	3	1
UCEC	p62 Lck ligand →	+0.380	+3.321	.004	.009	3	1
UCEC	PCNA →	+0.246	+3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GSK3-a-b by RARS2 expression — UCEC

Explore this box plot interactively →