RARS2

Across TCGA cell cohorts, RARS2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RARS2-associated genes across cancer lineages are IZUMO2, KRTAP17-1, and CENPVL3. Each is linked with RARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RARS2-to-partner and partner-to-RARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO2 grouped by RARS2-low versus RARS2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARS2→partner) and Y-score (partner→RARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IZUMO2 →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	KRTAP17-1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	CENPVL3 →	+0.703	+4.906	<.001	.006	3	1
BLOOD_Leukemia	LYZL2 →	+0.033	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	C1orf87 →	+0.025	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10G3 →	+0.046	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

IZUMO2 by RARS2 expression — OESOPHAGUS

Explore this box plot interactively →