RARS1

Across TCGA patient cohorts, RARS1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARS1-associated genes across cancer lineages are 14-3-3_beta, EGFR, and Ku80. Each is linked with RARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RARS1-to-partner and partner-to-RARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RARS1-low versus RARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARS1→partner) and Y-score (partner→RARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.091	-1.979	.024	.030	3	1
UCEC	EGFR →	-0.171	-1.906	.007	.016	3	1
UCEC	Ku80 →	+0.245	+3.013	.009	.018	3	1
UCEC	Annexin-1 →	+0.637	+2.341	.002	.019	3	1
UCEC	S6_pS240_S244 →	+0.360	+1.906	.027	.016	3	1
UCEC	VHL →	-0.825	-3.000	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by RARS1 expression — UCEC

Explore this box plot interactively →