RARS1

Across TCGA cell cohorts, RARS1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RARS1-associated genes across cancer lineages are WFDC12, DEFB4A, and CFHR2. Each is linked with RARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RARS1-to-partner and partner-to-RARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC12 grouped by RARS1-low versus RARS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARS1→partner) and Y-score (partner→RARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	CFHR2 →	+0.306	+6.124	<.001	<.001	3	1
LARGE_INTESTINE	RASGEF1C →	+0.226	+3.333	.004	.009	3	1
LARGE_INTESTINE	MAGEB1 →	+0.159	+2.878	.002	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

WFDC12 by RARS1 expression — BLOOD_Leukemia

Explore this box plot interactively →