RARRES2

Across TCGA pan-cancer cohorts, RARRES2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RARRES2 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher RARRES2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RARRES2 expression acts as an unfavorable survival marker, although some lineages such as MESO and LUAD show a favorable association.

MESO, KIRC, and UVM are the cancer types where RARRES2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.527	0.251	<.001	119	view →
KIRC	OS	Median	All	0.829	0.916	<.001	83	view →
UVM	DFS	Median	All	0.434	0.738	<.001	61	view →
OV	DFS	Tertile	III,IV	0.109	0.186	.002	54	view →
LUAD	OS	Tertile	II,III,IV	0.603	0.319	<.001	53	view →
LGG	DFS	Median	All	0.653	0.814	<.001	48	view →
SKCM	OS	Tertile	III,IV	0.527	0.262	.004	36	view →
DLBC	OS	Median	All	1.000	0.714	.001	35	view →
LUSC	OS	Quartile	All	0.283	0.483	.003	33	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.211	.010	30	view →
HNSC	DFS	Quartile	III,IV	0.427	0.131	<.001	27	view →
CHOL	DFS	Tertile	All	0.109	0.613	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RARRES2–MESO (OS)

Open the MESO breakdown →