RARRES1

Across TCGA patient cohorts, RARRES1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARRES1-associated genes across cancer lineages are Notch1, EGFR_pY1068, and TIGAR. Each is linked with RARRES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RARRES1-to-partner and partner-to-RARRES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RARRES1-low versus RARRES1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARRES1→partner) and Y-score (partner→RARRES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.223	+3.009	.002	.019	3	2
UCEC	EGFR_pY1068 →	-0.267	-3.321	.042	.010	3	1
UCEC	TIGAR →	+0.161	+2.196	.044	.034	3	1
UCEC	Tuberin →	+0.379	+3.009	.007	.019	3	1
UCEC	ATM →	-0.665	-3.000	.005	.036	3	1
UCEC	MEK1 →	+0.552	+3.321	.003	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by RARRES1 expression — UCEC

Explore this box plot interactively →