RARG

Across TCGA patient cohorts, RARG mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARG-associated genes across cancer lineages are p90 RSK_pT359_S363, Annexin-1, and S6_pS240_S244. Each is linked with RARG in more than 1 cancer types. Because this analysis shows association rather than direction, both RARG-to-partner and partner-to-RARG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK_pT359_S363 grouped by RARG-low versus RARG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARG→partner) and Y-score (partner→RARG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK_pT359_S363 →	-0.185	-2.584	.015	.010	3	2
UCEC	Annexin-1 →	+0.486	+2.604	.013	.005	3	2
UCEC	S6_pS240_S244 →	+0.352	+2.321	.021	.034	3	2
UCEC	TIGAR →	+0.135	+2.689	.018	<.001	3	2
UCEC	14-3-3_beta →	-0.084	-1.680	.025	.042	3	1
UCEC	eEF2 →	+0.479	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

p90 RSK_pT359_S363 by RARG expression — UCEC

Explore this box plot interactively →