RARG

Across TCGA cell cohorts, RARG mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RARG-associated genes across cancer lineages are NPY2R, IQCF6, and KCNU1. Each is linked with RARG in more than 1 cancer types. Because this analysis shows association rather than direction, both RARG-to-partner and partner-to-RARG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPY2R grouped by RARG-low versus RARG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARG→partner) and Y-score (partner→RARG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPY2R →	+0.004	+3.632	<.001	.003	3	1
LARGE_INTESTINE	IQCF6 →	+0.228	+3.882	<.001	.001	3	1
LARGE_INTESTINE	KCNU1 →	+0.041	+3.345	.001	.007	3	1
LARGE_INTESTINE	KRTAP7-1 →	+0.040	+4.022	<.001	.006	3	1
BLOOD_Leukemia	ASZ1 →	+0.124	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NPY2R by RARG expression — LARGE_INTESTINE

Explore this box plot interactively →