RAPSN

Across TCGA patient cohorts, RAPSN mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPSN-associated genes across cancer lineages are Notch1, A-Raf_pS299, and Gab2. Each is linked with RAPSN in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPSN-to-partner and partner-to-RAPSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RAPSN-low versus RAPSN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPSN→partner) and Y-score (partner→RAPSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.217	+1.916	<.001	.009	3	2
UCEC	A-Raf_pS299 →	-0.132	-3.584	.004	.002	3	1
UCEC	Gab2 →	+0.365	+2.000	.009	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.138	-1.700	.036	.042	3	1
UCEC	JNK2 →	+0.224	+1.584	.004	.036	3	1
UCEC	MEK1 →	+0.327	+2.000	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by RAPSN expression — UCEC

Explore this box plot interactively →