RAPSN

Across TCGA cell cohorts, RAPSN mutation is significantly associated with the mutation status of many other genes, with 6,289 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAPSN-associated genes across cancer lineages are PCDHA2, SLC9A1, and N4BP2. Each is linked with RAPSN in more than 3 cancer types. Because this analysis shows association rather than direction, both RAPSN-to-partner and partner-to-RAPSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHA2 grouped by RAPSN-low versus RAPSN-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPSN→partner) and Y-score (partner→RAPSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDHA2 →	+3.672	+4.307	.004	.004	1	4
LUNG_NSCLC_LUAD	SLC9A1 →	+5.772	+5.772	.002	.002	1	4
BLOOD_Leukemia	N4BP2 →	+2.823	+3.665	.008	.008	1	3
LARGE_INTESTINE	BCORL1 →	+1.678	+2.865	.006	.006	1	3
LUNG_NSCLC_LUAD	INO80D →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	PCDHB12 →	+4.187	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,289 associations by consensus.

PCDHA2 by RAPSN expression — URINARY_TRACT

Explore this box plot interactively →