RAPH1

Across TCGA patient cohorts, RAPH1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,856 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible RAPH1-associated genes across cancer lineages are ADGRF5, SEMA3G, and PCDH12. Each is linked with RAPH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RAPH1-to-partner and partner-to-RAPH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAPH1 versus ADGRF5 in CCRCC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPH1→partner) and Y-score (partner→RAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ADGRF5 →	+1.016	+0.341	<.001	<.001	3	5
CCRCC	SEMA3G →	+1.125	+0.279	<.001	<.001	3	4
CCRCC	PCDH12 →	+0.967	+0.344	<.001	<.001	3	4
BRCA	TMEM87A →	+0.406	+0.196	.004	.008	3	4
CCRCC	SEPTIN4 →	+0.662	+0.345	<.001	<.001	3	4
CCRCC	SMOC2 →	+1.539	+0.312	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,856 associations by consensus.

RAPH1 vs ADGRF5 — CCRCC

Explore this scatter interactively →