RAPH1

Across TCGA patient cohorts, RAPH1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPH1-associated genes across cancer lineages are NF2, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with RAPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAPH1-to-partner and partner-to-RAPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by RAPH1-low versus RAPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPH1→partner) and Y-score (partner→RAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.201	+1.906	.004	.014	3	3
COAD	Caspase-7-cleavedD198 →	+1.191	+2.815	.006	.036	3	2
COAD	c-Met_pY1235 →	+0.137	+2.849	.013	.034	3	2
UCEC	JNK2 →	+0.178	+1.222	.005	.035	3	2
UCEC	MSH6 →	-0.277	-2.000	.009	.029	3	2
UCEC	p27_pT198 →	+0.071	+2.459	.039	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

NF2 by RAPH1 expression — UCEC

Explore this box plot interactively →