RAPH1

Across TCGA cell cohorts, RAPH1 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAPH1-associated genes across cancer lineages are POM121L2, HSF5, and TECRL. Each is linked with RAPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPH1-to-partner and partner-to-RAPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121L2 grouped by RAPH1-low versus RAPH1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPH1→partner) and Y-score (partner→RAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POM121L2 →	+0.057	+3.146	.004	.009	3	2
SKIN	HSF5 →	+0.014	+3.921	<.001	.001	3	2
BREAST	TECRL →	+0.026	+5.169	<.001	.005	3	2
SOFT_TISSUE	MC2R →	+0.044	+4.392	<.001	.004	3	1
SOFT_TISSUE	OR2A5 →	+0.013	+4.392	<.001	.004	3	1
SOFT_TISSUE	RBMY1J →	+0.039	+4.515	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

POM121L2 by RAPH1 expression — CNS

Explore this box plot interactively →