RAPGEFL1

Across TCGA patient cohorts, RAPGEFL1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEFL1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Ku80. Each is linked with RAPGEFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEFL1-to-partner and partner-to-RAPGEFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RAPGEFL1-low versus RAPGEFL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEFL1→partner) and Y-score (partner→RAPGEFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.356	-3.584	.003	.002	3	1
UCEC	ERK2 →	+0.212	+3.584	.022	.002	3	1
UCEC	Ku80 →	+0.347	+2.472	.002	.011	3	1
UCEC	MAPK_pT202_Y204 →	-0.718	-3.321	.001	.010	3	1
UCEC	MEK1_p_S217_S221 →	-0.408	-3.321	.001	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.654	-3.000	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by RAPGEFL1 expression — UCEC

Explore this box plot interactively →