RAPGEF6

Across TCGA patient cohorts, RAPGEF6 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,745 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible RAPGEF6-associated proteins across cancer lineages are RPS8_S160, THUMPD1, and C5orf24. Each is linked with RAPGEF6 in more than 4 cancer types. Because this analysis shows association rather than direction, both RAPGEF6-to-partner and partner-to-RAPGEF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAPGEF6 versus RPS8_S160 in GBM, with a Pearson correlation of -0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF6→partner) and Y-score (partner→RAPGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS8_S160 →	-0.754	-0.531	<.001	<.001	3	5
BRCA	THUMPD1 →	+0.302	+0.390	<.001	<.001	3	5
GBM	C5orf24 →	+0.283	+0.416	.001	<.001	3	4
BRCA	FBXO38 →	+0.464	+0.425	<.001	<.001	3	4
LSCC	GKAP1 →	+0.612	+0.366	<.001	<.001	3	4
GBM	RPL3 →	-0.411	-0.413	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,745 associations by consensus.

RAPGEF6 vs RPS8_S160 — GBM

Explore this scatter interactively →