RAPGEF6

Across TCGA patient cohorts, RAPGEF6 mutation is significantly associated with the RNA expression of many other genes, with 3,439 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF6-associated genes across cancer lineages are RPL23AP82, KIF18B, and LONP1. Each is linked with RAPGEF6 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAPGEF6-to-partner and partner-to-RAPGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by RAPGEF6-low versus RAPGEF6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF6→partner) and Y-score (partner→RAPGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP82 →	+0.578	+2.144	<.001	.009	3	4
UCEC	KIF18B →	+0.534	+2.332	.001	<.001	3	4
UCEC	LONP1 →	+0.583	+2.010	<.001	<.001	3	4
UCEC	GTSE1 →	+0.540	+2.402	<.001	<.001	3	4
UCEC	DDX55 →	+0.270	+1.299	.006	.004	3	4
HNSC	LINC02704 →	+0.566	+3.799	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,439 associations by consensus.

RPL23AP82 by RAPGEF6 expression — SKCM

Explore this box plot interactively →