RAPGEF6

Across TCGA patient cohorts, RAPGEF6 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF6-associated genes across cancer lineages are FoxM1, Notch1, and p62 Lck ligand. Each is linked with RAPGEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF6-to-partner and partner-to-RAPGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RAPGEF6-low versus RAPGEF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF6→partner) and Y-score (partner→RAPGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.159	+1.115	.034	.026	3	2
UCEC	Notch1 →	+0.112	+1.295	.006	.010	3	2
UCEC	p62 Lck ligand →	+0.396	+2.736	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.171	-2.000	<.001	<.001	3	2
UCEC	TIGAR →	+0.088	+1.322	.046	.006	3	2
UCEC	4E-BP1 →	+0.268	+2.087	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FoxM1 by RAPGEF6 expression — UCEC

Explore this box plot interactively →