RAPGEF6

Across TCGA cell cohorts, RAPGEF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,500 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAPGEF6-associated GO terms across cancer lineages are Microtubule organizing center organization, Phosphatidylinositol metabolic process, and Microtubule polymerization. Each is linked with RAPGEF6 in more than 15 cancer types. Because this analysis shows association rather than direction, both RAPGEF6-to-partner and partner-to-RAPGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule organizing center organization grouped by RAPGEF6-low versus RAPGEF6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF6→partner) and Y-score (partner→RAPGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Microtubule organizing center organization →	+0.083	+0.559	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.062	+1.086	<.001	<.001	3	16
LARGE_INTESTINE	Microtubule polymerization →	+0.104	+0.532	<.001	<.001	3	16
PANCREAS	Centrosome cycle →	+0.086	+0.875	<.001	<.001	3	16
STOMACH	Positive regulation of microvillus assembly →	+0.143	+1.009	<.001	<.001	3	15
OVARY	Protein localization to chromosome →	+0.083	+0.580	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,500 associations by consensus.

Microtubule organizing center organization by RAPGEF6 expression — BREAST

Explore this box plot interactively →