RAPGEF5

Across TCGA patient cohorts, RAPGEF5 mutation is significantly associated with the RNA expression of many other genes, with 2,853 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF5-associated genes across cancer lineages are TRDD1, HNRNPH3P1, and MIR4675. Each is linked with RAPGEF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF5-to-partner and partner-to-RAPGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDD1 grouped by RAPGEF5-low versus RAPGEF5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF5→partner) and Y-score (partner→RAPGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRDD1 →	+0.682	+7.473	<.001	.007	3	2
BRCA	HNRNPH3P1 →	+0.064	+5.505	<.001	.002	3	2
COAD	MIR4675 →	+0.597	+5.375	<.001	<.001	3	2
SKCM	RN7SL141P →	+0.043	+1.814	.009	.006	3	2
SKCM	MIR668 →	+0.050	+4.173	<.001	.003	3	2
CESC	TTTY12 →	+0.067	+6.397	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,853 associations by consensus.

TRDD1 by RAPGEF5 expression — BRCA

Explore this box plot interactively →