RAPGEF5

Across TCGA patient cohorts, RAPGEF5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF5-associated genes across cancer lineages are mTOR_pS2448, Annexin-1, and Caspase-7-cleavedD198. Each is linked with RAPGEF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF5-to-partner and partner-to-RAPGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by RAPGEF5-low versus RAPGEF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF5→partner) and Y-score (partner→RAPGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.145	-2.489	.002	.001	3	2
UCEC	Annexin-1 →	+0.524	+2.807	.002	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.588	+1.434	.002	.027	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.768	+2.700	.001	.006	2	2
SKCM	Rb →	+0.200	+2.700	.005	.006	3	1
SKCM	c-Met →	+0.150	+2.017	.022	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by RAPGEF5 expression — UCEC

Explore this box plot interactively →