RAPGEF5

Across TCGA cell cohorts, RAPGEF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,411 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAPGEF5-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of cell fate commitment, and D-glucuronate catabolic process to D-xylulose 5-phosphate. Each is linked with RAPGEF5 in more than 10 cancer types. Because this analysis shows association rather than direction, both RAPGEF5-to-partner and partner-to-RAPGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by RAPGEF5-low versus RAPGEF5-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF5→partner) and Y-score (partner→RAPGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.101	+1.167	.004	.009	2	11
STOMACH	Negative regulation of cell fate commitment →	-0.653	-1.327	.009	.002	2	10
BREAST	D-glucuronate catabolic process to D-xylulose 5-phosphate →	+0.153	+1.073	<.001	.001	2	10
BREAST	D-glucuronate catabolic process →	+0.153	+1.073	<.001	.001	2	10
BREAST	Glucuronate catabolic process →	+0.153	+1.073	<.001	.001	2	10
BLOOD_Lymphoma	Response to molecule of fungal origin →	+1.444	+2.010	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,411 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by RAPGEF5 expression — KIDNEY

Explore this box plot interactively →