RAPGEF5

Across TCGA cell cohorts, RAPGEF5 mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAPGEF5-associated genes across cancer lineages are EFCC1, TBX22, and CDKN1C. Each is linked with RAPGEF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF5-to-partner and partner-to-RAPGEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EFCC1 grouped by RAPGEF5-low versus RAPGEF5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF5→partner) and Y-score (partner→RAPGEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EFCC1 →	+0.053	+2.252	.005	.005	3	1
SKIN	TBX22 →	+0.113	+2.714	.001	.008	3	1
SKIN	CDKN1C →	+1.370	+3.364	<.001	.002	3	1
SKIN	FAM104A →	-0.478	-3.192	.002	.006	3	1
SKIN	SULT6B1 →	+0.088	+2.727	<.001	<.001	3	1
SKIN	AMT →	+0.676	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

EFCC1 by RAPGEF5 expression — SKIN

Explore this box plot interactively →