RAPGEF4

Across TCGA patient cohorts, RAPGEF4 protein abundance is significantly associated with the protein abundance of many other proteins, with 25,609 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RAPGEF4-associated proteins across cancer lineages are EHD3, RAB11FIP2, and RANBP2. Each is linked with RAPGEF4 in more than 4 cancer types. Because this analysis shows association rather than direction, both RAPGEF4-to-partner and partner-to-RAPGEF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAPGEF4 versus EHD3 in GBM, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF4→partner) and Y-score (partner→RAPGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EHD3 →	+0.744	+0.700	<.001	<.001	3	5
OV	RAB11FIP2 →	+0.536	+0.555	.002	.003	3	4
OV	RANBP2 →	-0.434	-0.917	<.001	<.001	3	4
GBM	TMOD2 →	+0.603	+0.801	<.001	<.001	3	4
CCRCC	TNS2 →	+0.406	+0.387	<.001	<.001	3	4
GBM	SHANK3 →	+0.660	+0.803	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,609 associations by consensus.

RAPGEF4 vs EHD3 — GBM

Explore this scatter interactively →