RAPGEF4

Across TCGA patient cohorts, RAPGEF4 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF4-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with RAPGEF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAPGEF4-to-partner and partner-to-RAPGEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RAPGEF4-low versus RAPGEF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF4→partner) and Y-score (partner→RAPGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.463	-3.234	<.001	<.001	3	3
UCEC	eEF2 →	+0.322	+2.906	.001	.001	3	2
UCEC	eIF4E →	+0.164	+4.013	.004	<.001	3	2
UCEC	ERK2 →	+0.154	+1.652	.003	.005	3	2
UCEC	FoxM1 →	+0.144	+1.050	.044	.023	3	2
UCEC	GAPDH →	+0.440	+2.502	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ATM by RAPGEF4 expression — UCEC

Explore this box plot interactively →