RAPGEF4

Across TCGA cell cohorts, RAPGEF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,601 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RAPGEF4-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with RAPGEF4 in more than 11 cancer types. Because this analysis shows association rather than direction, both RAPGEF4-to-partner and partner-to-RAPGEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by RAPGEF4-low versus RAPGEF4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF4→partner) and Y-score (partner→RAPGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of myoblast fusion →	+0.108	+0.434	<.001	<.001	3	12
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.161	+1.366	<.001	<.001	3	12
STOMACH	Regulation of myoblast fusion →	+0.145	+1.341	<.001	<.001	3	12
OVARY	Cytoplasmic translation →	+0.079	+0.382	.002	.005	1	12
LUNG_SCLC	Aerobic respiration →	+0.081	+1.334	.001	.005	3	9
OVARY	Nucleoside triphosphate metabolic process →	+0.057	+0.452	<.001	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,601 associations by consensus.

Negative regulation of myoblast fusion by RAPGEF4 expression — OVARY

Explore this box plot interactively →