RAPGEF4

Across TCGA cell cohorts, RAPGEF4 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RAPGEF4-associated genes across cancer lineages are TDGF1, IQCF1, and HPGDS. Each is linked with RAPGEF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF4-to-partner and partner-to-RAPGEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDGF1 grouped by RAPGEF4-low versus RAPGEF4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF4→partner) and Y-score (partner→RAPGEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TDGF1 →	+0.249	+3.209	.002	.005	3	2
LUNG_SCLC	IQCF1 →	+0.115	+3.898	<.001	.005	3	2
SKIN	HPGDS →	+0.053	+3.453	.001	.009	3	2
CNS	PABPC5 →	+0.466	+3.980	.002	.002	3	2
LUNG_SCLC	APOA4 →	+0.367	+3.898	.005	.005	3	1
LUNG_SCLC	SEMG1 →	+0.015	+4.169	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

TDGF1 by RAPGEF4 expression — PANCREAS

Explore this box plot interactively →