RAPGEF3

Across TCGA patient cohorts, RAPGEF3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF3-associated genes across cancer lineages are Bax, STAT3_pY705, and Chk2. Each is linked with RAPGEF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAPGEF3-to-partner and partner-to-RAPGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by RAPGEF3-low versus RAPGEF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF3→partner) and Y-score (partner→RAPGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.269	+1.847	.002	.008	3	3
UCEC	STAT3_pY705 →	-0.464	-2.999	<.001	<.001	3	2
SKCM	Chk2 →	+0.218	+2.321	.012	.033	3	2
UCEC	NF-kB-p65_pS536 →	-0.415	-3.321	.012	.009	3	2
UCEC	PEA-15_pS116 →	+0.296	+1.502	.021	.030	3	2
UCEC	Rad50 →	-0.207	-1.502	.020	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Bax by RAPGEF3 expression — UCEC

Explore this box plot interactively →