RAPGEF3

Across TCGA cell cohorts, RAPGEF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,142 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RAPGEF3-associated GO terms across cancer lineages are Regulation of angiogenesis, Regulation of vasculature development, and Vertebrate eye-specific patterning. Each is linked with RAPGEF3 in more than 9 cancer types. Because this analysis shows association rather than direction, both RAPGEF3-to-partner and partner-to-RAPGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of angiogenesis grouped by RAPGEF3-low versus RAPGEF3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF3→partner) and Y-score (partner→RAPGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of angiogenesis →	+0.083	+2.203	<.001	<.001	3	10
OESOPHAGUS	Regulation of vasculature development →	+0.062	+1.607	<.001	.002	3	10
OVARY	Vertebrate eye-specific patterning →	+1.131	+2.021	.001	.005	3	9
SOFT_TISSUE	Host-mediated suppression of symbiont invasion →	+0.163	+1.478	.003	.001	3	9
OESOPHAGUS	Negative regulation of actin filament polymerization →	+0.142	+1.824	<.001	.001	3	9
LIVER	Negative regulation of protein-containing complex assembly →	+0.099	+1.139	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,142 associations by consensus.

Regulation of angiogenesis by RAPGEF3 expression — OESOPHAGUS

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