RAPGEF2

Across TCGA cell cohorts, RAPGEF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,162 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAPGEF2-associated GO terms across cancer lineages are Negative regulation of secondary metabolite biosynthetic process, Negative regulation of melanin biosynthetic process, and Negative regulation of dendrite morphogenesis. Each is linked with RAPGEF2 in more than 17 cancer types. Because this analysis shows association rather than direction, both RAPGEF2-to-partner and partner-to-RAPGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of secondary metabolite biosynthetic process grouped by RAPGEF2-low versus RAPGEF2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF2→partner) and Y-score (partner→RAPGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of secondary metabolite biosynthetic process →	+0.204	+1.023	<.001	<.001	3	18
PANCREAS	Negative regulation of melanin biosynthetic process →	+0.204	+1.023	<.001	<.001	3	18
SOFT_TISSUE	Negative regulation of dendrite morphogenesis →	+0.211	+1.570	<.001	<.001	3	18
OESOPHAGUS	Brain-derived neurotrophic factor receptor signaling pathway →	+1.185	+0.769	<.001	<.001	3	18
SOFT_TISSUE	Response to cGMP →	+1.407	+2.399	<.001	<.001	3	18
URINARY_TRACT	Cellular response to cGMP →	+1.636	+1.364	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,162 associations by consensus.

Negative regulation of secondary metabolite biosynthetic process by RAPGEF2 expression — PANCREAS

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