RAPGEF2

Across TCGA cell cohorts, RAPGEF2 mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAPGEF2-associated genes across cancer lineages are ZNF232, C16orf92, and UCMA. Each is linked with RAPGEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF2-to-partner and partner-to-RAPGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF232 grouped by RAPGEF2-low versus RAPGEF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF2→partner) and Y-score (partner→RAPGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF232 →	+0.725	+3.087	.001	.006	3	2
SKIN	C16orf92 →	+0.034	+4.415	<.001	<.001	3	2
BLOOD_Leukemia	UCMA →	+0.046	+2.604	.001	.006	3	2
CNS	LRIT1 →	+0.415	+3.137	.001	.001	3	2
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	OR4F4 →	+0.012	+3.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

ZNF232 by RAPGEF2 expression — LARGE_INTESTINE

Explore this box plot interactively →