RAPGEF1

Across TCGA patient cohorts, RAPGEF1 RNA expression is significantly associated with the mutation status of many other genes, with 8,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF1-associated genes across cancer lineages are TP53, LTBP2, and ABCC8. Each is linked with RAPGEF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RAPGEF1-to-partner and partner-to-RAPGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by RAPGEF1-low versus RAPGEF1-high in GBM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF1→partner) and Y-score (partner→RAPGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TP53 →	+2.584	+0.500	<.001	<.001	3	5
UCEC	LTBP2 →	+2.617	+0.430	<.001	<.001	3	3
UCEC	ABCC8 →	+2.295	+0.410	<.001	<.001	3	3
UCEC	MYOM1 →	+1.576	+0.378	<.001	<.001	3	3
UCEC	CDH11 →	+1.617	+0.333	<.001	<.001	3	3
UCEC	TMC2 →	+4.424	+0.471	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,786 associations by consensus.

TP53 by RAPGEF1 expression — GBM

Explore this box plot interactively →